If you’re experiencing pain, swelling, or inflammation due to an injury or chronic condition, Zerodol SP Tablet may be a medication your doctor has prescribed. This combination tablet is commonly used for relief from pain associated with muscle strains, arthritis, dental pain, and post-operative conditions. But what exactly is Zerodol SP? How does it work, and is it safe for everyone to use? Let’s break it down in simple terms.

Table of Contents
Zerodol SP Tablet: Uses, Benefits, Side Effects & Substitutes, FAQs and more
Zerodol SP is a prescription medication that combines three active ingredients:
- Aceclofenac (100 mg): A powerful anti-inflammatory that reduces pain and swelling.
- Serratiopeptidase (15 mg): An enzyme that breaks down abnormal proteins at the site of inflammation, helping reduce swelling.
- Paracetamol (Acetaminophen) (325 mg): A mild painkiller and fever reducer.
Together, these ingredients work in synergy to effectively manage both pain and inflammation.
Uses of Zerodol SP Tablet
Zerodol SP tablet is commonly used for:
- Muscle or joint pain
- Osteoarthritis and rheumatoid arthritis
- Post-surgical pain and swelling
- Back pain or slipped disc
- Dental pain
- Trauma or injury-related inflammation
How Does It Work?
- Aceclofenac blocks the action of certain chemical messengers (prostaglandins) that cause pain and swelling.
- Paracetamol helps relieve mild to moderate pain and reduces fever.
- Serratiopeptidase helps dissolve the protein-based fluids at injury sites, promoting faster healing and less swelling.
This combo not only reduces pain but also accelerates recovery.

Dosage & How to Take
- Usually taken 1 tablet twice a day, after food, or as directed by your doctor.
- Swallow it whole with water—do not crush or chew.
- Stick to the prescribed dose; do not self-medicate or skip doses.
Side Effects of Zerodol SP Tablet
Like any medicine, Zerodol-SP may cause some side effects. Most are mild and go away with time.
Common side effects:
- Nausea or vomiting
- Diarrhea or constipation
- Stomach pain or acidity
- Dizziness or drowsiness
- Loss of appetite
Serious (but rare) side effects:
- Stomach ulcers or bleeding
- Liver or kidney issues
- Allergic reactions like rash, swelling, or breathing difficulty
Always inform your doctor if you experience any unusual symptoms.

Precautions to Take
- Not recommended during pregnancy or breastfeeding unless advised by a doctor.
- Avoid alcohol while taking Zerodol-SP, which can increase the risk of liver damage.
- People with liver, kidney, or heart conditions should use it with caution.
- Don’t take it with other NSAIDs or painkillers unless prescribed.
Substitutes for Zerodol SP Tablet
If Zerodol-SP is unavailable, doctors may prescribe alternatives such as:
- Aceclo-SP
- Movon-SP
- Acenac-SP
- Dolokind-SP
Always check with your healthcare provider before switching.
Here, you will get all the information about the Plix Glutathione
Q1. Can Zerodol-SP be taken on an empty stomach?
Q2. Is it safe for long-term use?
Q3. Can I take Zerodol-SP with antibiotics?
Q4. Is Zerodol-SP habit-forming?
Q5. Can it be used for fever?
Conclusion
Zerodol SP Tablet is a potent painkiller that provides quick and effective relief from pain, inflammation, and swelling. Whether it’s a sports injury, arthritis, or post-surgical recovery, this medicine can play a valuable role in your healing journey. Just make sure to follow your doctor’s advice and never self-medicate.